Introduction
Subcutaneous tissue inoculation in murine preclinical model is an efficient andcost-effective way to evaluate in vivo the response of tumors to novel therapies. Thetumoral cells are implanted into the flank of a mice. Tumor is then usually assessed usinga caliper, the current gold standard method to monitor the volume growth. The caliperhas however some limitations. It cannot distinguish the tumor itself from the surroundinginflammatory or fibrotic tissue. It is also an invasive method that measures only theexternal surface of a tumor ignoring larger and deeper lesion. On contrary, MRI is a noninvasiveapproach that allows (1) a 3D assessment of the tumoral volume (2) and in vivomonitoring of lesional growth. This project aims at showing that MRI provides betteraccuracy and reliability compared to caliper measurements for assessing subcutaneoustumors, supporting its broader application in large-scale preclinical oncology studies.
